Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors depending on each SARM’s chemical structure. Consequently, SARMs bring about anabolic cellular activity while avoiding lots of the side effects of now available anabolic steroids. SARMs are already studied inside the treating breast cancers and cachexia and have recently been used as performance-enhancing agents. Here, we evaluate and summarize the present literature on SARMs.
Aim
Presenting the background, mechanisms, current and potential clinical applications, along with risks and advantages of SARMs.
Methods
A literature review was performed in MEDLINE while using the terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancer, benign prostatic hyperplasia, libido, and lean muscle mass. Both basic research and studies were included.
Main Outcome Measure
To accomplish an assessment of peer-reviewed literature.
Results
However, there are no U.S. Drug and food Agency-approved indications for SARMs, investigators are studying the potential ways to use these compounds. Research has devoted to the pharmacokinetics and pharmacodynamics of these agents, demonstrating good availability having a paucity of drug interactions. Early clinical studies have demonstrated potential ways to use SARMs from the treatment of cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and cancers of the breast, with positive results.
Conclusion
SARMs have several possible clinical applications, with promise to the safe use within treating cachexia, BPH, hypogonadism, breast cancer, and prostate cancer.
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