SINCE World War II, medical science has progressed into a stage where competitive medications are around for treat the same ailment in numerous people. This is not pretty much brands (that is a trade issue) but generic drugs (that is a scientific issue). Within this report, we shall glance at the various factors that decide the selection of a certain drug.
Safety: These sub-criteria should be considered under the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is a particular drug even though it’s certain side-effects providing the acuteness with the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but feature the potential side-effect of addiction.
* Long-term safety: medication directory may be safe in short-term treatment, but how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case there is prolonged use.
* Drug-drug interaction risk: Prescription medication is chemicals, and several chemicals respond to develop a different chemical, which has an effect that may harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from the other person, have certain effects on one or more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends on due to the metabolism. This causes a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually produce the same influence on the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of the two medicines are more intense.
Tolerability: A medicine may be effective however, not tolerable by all patients. Example: Allergies to particular drugs in a few people. Short-term and long-term tolerability must be considered. Efficacy: A medicine is not equally effective in all patients. For instance, some patients with depression or panic attacks experience reduced escitalopram, but there are several who don’t, who therefore must be prescribed an alternative anti-depressant. The pace of oncoming of therapeutic action is a the answer to be regarded as too.
Cost: Cost does not mean the expense of purchase of a certain medicine alone. It must also cover the expense of treatments for a complication that may arise from using an alternative drug. Example: Inside a individual that insists on taking alcohol and yet should be treated for depression is normally administered an SSRI drug since these drugs don’t potentiate the results of alcohol, whereas another band of anti-depressants (including tricyclics) can cause a new overuse injury in such patients, which could have to have a various and expensive treatment. Therefore, it’s preferable to prescribe the more expensive escitalopram as opposed to a cheaper tricyclic such patients.
Simplicity of treatment: Most effective mode of administration is preferred. If there is a selection between an injection and oral administration, aforementioned is preferred in the event the efficacy of the two modes can be compared. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are key point to choose simple treatment.
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