SINCE World War II, medical science has progressed into a stage where competitive medications are available to treat the identical ailment in numerous people. This isn’t nearly brands (which is a trade issue) but generic drugs (which is a scientific issue). On this report, we shall go through the various factors that decide the selection of a certain drug.
Safety: These sub-criteria have to be considered within the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective is a particular drug even when it’s got certain side-effects provided that the acuteness from the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but have the potential side-effect of addiction.
* Long-term safety: medication could be safe in short-term treatment, so how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and a lot of chemicals respond to create a different chemical, which has an effect which could harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from each other, have certain effects using one or higher body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by because of its metabolism. This leads to an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually create the same influence on the identical organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both medicine is more serious.
Tolerability: A medication could be effective and not tolerable by all patients. Example: Allergies to certain drugs in certain people. Short-term and long-term tolerability have to be taken into consideration. Efficacy: A medication just isn’t equally good at all patients. For instance, some patients with depression or panic attacks experience reduced escitalopram, but there are many that don’t, who therefore have to be prescribed an alternative anti-depressant. The interest rate of oncoming of therapeutic action is a key to be considered too.
Cost: Cost does not necessarily mean the expense of purchase of a certain medicine alone. It must also cover the expense of treatment of a complication which could arise while using an alternative drug. Example: In a person who insists on taking alcohol nevertheless has to be treated for depression is generally administered an SSRI drug because they drugs don’t potentiate the results of alcohol, whereas another band of anti-depressants (like tricyclics) may cause a whole new overuse injury in such patients, which would have to have a different and expensive treatment. Therefore, it’s better to prescribe the more expensive escitalopram rather than a cheaper tricyclic in this patients.
Simplicity of treatment: The simplest mode of administration is preferred. If there is a choice between a shot and oral administration, rogues is preferred if your efficacy of both modes can be compared. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are a key factor to decide simplicity of treatment.
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